Objective To explore the intervention effects of rehabilitation training of mode of human occupation （MOHO） on self-efficacy and stigma of convalescent schizophrenic patients. Methods 103 inpatients with schizophrenia were randomly divided into a research group（53 cases） and a control group（50 cases）. The study group received a rehabilitation training of MOHO on the basis of anti-psychotic treatment and routine nursing, 5 times a week for 8 weeks. The control group received a routine rehabilitation training on the basis of anti-psychotic treatment and routine nursing. Before and after the intervention,the general self-efficacy scale（GSES） and the stigma scale for patients with mental illness（SSMI-C） were used to evaluate the effect of the intervention. Results The results of intra group comparison showed that GSES was（15.46±2.74） before intervention and（17.92 ±2.42） after intervention. Before the intervention,the total score of stigma was（52.12±7.53）,discrimination was （21.36±6.83）,disease concealment was （17.28±4.45）,positive effect was（13.48±3.81）;after the intervention,the total score of stigma was （41.66±4.95）,discrimination was（16.84±4.02）,disease concealment was （14.18±2.75）,and positive effect was（10.64±2.38）. The difference was statistically significant（P<0.001）. The comparison results within the control group showed that the post test score of self-efficacy was higher than the pretest score,and there was no significant difference in GSES score,total score of stigma,discrimination,disease concealment and positive effect factor score（P>0.05）. After the intervention,the GSES score of the research group was higher than that of the control group,and the total score and each dimension score of stigma were lower than those of the control group（P<0.001）. Conclusion The rehabilitation training of MOHO can effectively reduce the level of stigma and improve the sense of self-efficacy.